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max in WT synaptoneurosomes, suggesting that Src signaling may very well be downregulated in KI synapses. However, our ability to rescue SERT function in KI midbrain synaptoneurosomes from the inhibition of FAK indicates elevated FAK signaling downstream from the Pro32Pro33 mutant, as confirmed by increased pFAK localization in five-HT synapses. Ou